On Burn Wounds and Skin Grafts
While large-scale trials are more common in DFUs, case studies and reviews show PDRN’s powerful effect on thermal injuries.
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Key Case Report: Chronic Non-Healing Burn Wound A case report detailed a patient with a severe, chronic non-healing wound from a third-degree burn that had failed to respond to other advanced treatments (like skin grafts and negative pressure therapy).
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Finding: The patient received three PDRN injections at the wound site.
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Result: The treatment led to a dramatic improvement and full epithelialization (skin closure). The study concluded that PDRN application represented a potential treatment for refractory (stubborn) wounds, potentially avoiding the need for more invasive surgeries.
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Systematic Review (2021) A comprehensive review paper covering 25 years of research confirmed PDRN’s role in skin regeneration. It specifically highlighted that PDRN’s ability to reduce inflammation, promote cell growth, and stimulate angiogenesis (new blood vessels) makes it highly effective for impaired healing processes, such as those caused by thermal injury (burns).
Link to full study : Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers.